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About Histone deacetylase

About Histone deacetylase E7qQR
It's honor to me to contact you Prof. Giovina Ruberti. My name is Ahmed Mohsen Kamal, I'm a demonstrator at medicinal chemistry department-faculty of pharmacy-Assiut university-Egypt I'm working on synthesis new norfloxacin derivatives with possible antibacterial, antimycobacterial and anticancer activity. My new compounds were exposed to in-silico studies through molecular modelling and showed promising activity on histone deacetylase enzyme more than norfloxacin and SAHA. I wonder if there's any possibility to cooperate with you prof and make screening for my new compounds to determine their anticancer activity and their inhibitory effect on histone deacetylase enzyme. I have attached an excel spreadsheet with the results so far. We have all MICs against E. coli. There are several compounds with quite a good MIC, two with an MIC comparable to Nor, and one with an even better MIC. We have tested all compounds against P. aeruginosa. Less of them are active, but we have at least three with an MIC ≤ 1, which we will test again together with Nor and Cip. We have done mode of action confirmation for gyrase in E. coli, where we selected the best compounds of each series, 19 in total. 18 of those show a phenotype consistent with gyrase inhibition. We have tested off-target activity on the inner membrane of E. coli and none of the 19 tested compounds showed any effects. Next week, we plan to test outer membrane activity in E. coli with the best representative of each series. M. tuberculosis is still growing slowly. We will wait until the cultures are ready to complete the MIC assays (and we do not have 96-well plates at the moment because Covid testing has depleted the supply in Sweden, so we have to wait for that, too). Once Mtb is in log phase and we have the plates, we will test MICs against Mtb, test lower concentrations of the three best compounds against P. aeruginosa, and test S. aureus as well. After that, we will test the best compounds against quinolone-resistant P. aeruginosa and S. aureus. Then we will test effects on peptidoglycan synthesis in Gram-positives with the compounds that are most active against S. aureus. So that is the plan. Unfortunately, I cannot tell you exactly when Mtb will be ready and when we will have plates again, but I made an estimate in the excel file. I will send you updated versions of the spreadsheet when results come in.
It's honor to me to contact you Prof.
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Giovina
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Ruberti
.

My name
is Ahmed
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Mohsen
Kamal, I'm a demonstrator at medicinal chemistry department-faculty of
Possible spelling mistake found.
pharmacy-Assiut
university-Egypt

I'm working on synthesis new
Possible spelling mistake found.
norfloxacin
derivatives with possible antibacterial,
Possible spelling mistake found.
antimycobacterial
and anticancer
You use this word too often, consider replacing it with
activity
. My new compounds
were exposed
to
Possible spelling mistake found.
in-silico
studies through molecular modelling and
This phrase/word (depending on the context) can be potentially replaced with :
showed
promising
You use this word too often, consider replacing it with
activity
on histone
Possible spelling mistake found.
deacetylase
enzyme more than
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norfloxacin
and
Possible spelling mistake found.
SAHA
. I wonder if there's any possibility to cooperate with you prof and
This phrase/word (depending on the context) can be potentially replaced with :
make
screening for my new compounds to determine their anticancer
You use this word too often, consider replacing it with
activity
and their inhibitory effect on histone
Possible spelling mistake found.
deacetylase
enzyme.

I have attached an
"Excel" is a proper noun and needs to be capitalized.
excel
spreadsheet with the results
This phrase/word is too simple and can be replaced with:
so
far. We have all
Possible spelling mistake found.
MICs
against E. coli. There are several compounds with quite a
This phrase/word (depending on the context) can be potentially replaced with :
good
MIC, two with an MIC comparable to Nor, and one with an even better MIC. We have
This phrase/word (depending on the context) can be potentially replaced with :
tested
all compounds against P.
Possible spelling mistake found.
aeruginosa
. Less of them are active,
This phrase/word is too simple and can be replaced with:
but
we have at least three with an MIC ≤ 1, which we will
You use this word too often, consider replacing it with
test
again together with Nor and
Possible spelling mistake found.
Cip
.

We have done mode of action confirmation for
Possible spelling mistake found.
gyrase
in E. coli, where we selected the
You use this word too often, consider replacing it with
best
compounds of each series, 19 in total. 18 of those
This phrase/word (depending on the context) can be potentially replaced with :
show
a phenotype consistent with
Possible spelling mistake found.
gyrase
inhibition. We have
This phrase/word (depending on the context) can be potentially replaced with :
tested
off-target
You use this word too often, consider replacing it with
activity
on the inner membrane of E. coli and none of the 19
This phrase/word (depending on the context) can be potentially replaced with :
tested
compounds
This phrase/word (depending on the context) can be potentially replaced with :
showed
any effects.

Next
week, we plan to
You use this word too often, consider replacing it with
test
outer membrane
You use this word too often, consider replacing it with
activity
in E. coli with the
You use this word too often, consider replacing it with
best
representative of each series. M. tuberculosis is
still
growing
slowly
. We will wait until the cultures are ready to complete the MIC assays (and we do not have 96-well plates at the moment
This phrase/word is too simple and can be replaced with:
because
Did you mean "COVID-19" or the alternative spelling "Covid-19" (= coronavirus)?
Covid
testing has depleted the supply in Sweden,
This phrase/word is too simple and can be replaced with:
so
we
This phrase/word is too simple and can be replaced with:
have to
wait for that, too). Once
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Mtb
is in log
Use a comma before 'and' if it connects two independent clauses (unless they are closely connected and short).
phase and
we have the plates, we will
You use this word too often, consider replacing it with
test
Possible spelling mistake found.
MICs
against
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Mtb
,
You use this word too often, consider replacing it with
test
lower concentrations of the three
You use this word too often, consider replacing it with
best
compounds against P.
Possible spelling mistake found.
aeruginosa
, and
You use this word too often, consider replacing it with
test
S. aureus
as well
.

After that, we will
You use this word too often, consider replacing it with
test
the
You use this word too often, consider replacing it with
best
compounds against
Possible spelling mistake found.
quinolone-resistant
P.
Possible spelling mistake found.
aeruginosa
and S. aureus. Then we will
You use this word too often, consider replacing it with
test
effects on peptidoglycan synthesis in Gram-positives with the compounds that are most active against S. aureus.
This phrase/word is too simple and can be replaced with:
So
that is
the plan. Unfortunately, I cannot
This phrase/word (depending on the context) can be potentially replaced with :
tell
you exactly when
Possible spelling mistake found.
Mtb
will be ready and when we will have plates again,
This phrase/word is too simple and can be replaced with:
but
I made an estimate in the
"Excel" is a proper noun and needs to be capitalized.
excel
file. I will
This phrase/word (depending on the context) can be potentially replaced with :
send
you updated versions of the spreadsheet when results
This phrase/word (depending on the context) can be potentially replaced with :
come
in.
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IELTS essay About Histone deacetylase

Essay
  American English
6 paragraphs
405 words
5.5
Overall Band Score
Coherence and Cohesion: 5.5
  • Structure your answers in logical paragraphs
  • ?
    One main idea per paragraph
  • Include an introduction and conclusion
  • Support main points with an explanation and then an example
  • Use cohesive linking words accurately and appropriately
  • Vary your linking phrases using synonyms
Lexical Resource: 5.0
  • Try to vary your vocabulary using accurate synonyms
  • Use less common question specific words that accurately convey meaning
  • Check your work for spelling and word formation mistakes
Grammatical Range: 6.5
  • Use a variety of complex and simple sentences
  • Check your writing for errors
Task Achievement: 5.0
  • Answer all parts of the question
  • ?
    Present relevant ideas
  • Fully explain these ideas
  • Support ideas with relevant, specific examples
Labels Descriptions
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  • Meet the criteria
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