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This thesis proposes the hypothesis that there are proteins present in the peritoneal dialysis effluent that will inform on the rate of simple peritoneal sclerosis and EPS.

This thesis proposes the hypothesis that there are proteins present in the peritoneal dialysis effluent that will inform on the rate of simple peritoneal sclerosis and EPS. These proteins are likely to be those involved in tissue remodeling or fibrosis. MMPs, TIMPs, and proteins identified by proteomics are examples on these potential proteins. To address this, each chapter sought to parts of this wider hypothesis. Chapter 3 proposed that changes in the MMP system in the peritoneum would underlie PS &/or the switch to EPS and may 244 have value as biomarkers or diagnostics in PDE while chapter 4 tested the hypothesis that MMP family members had a peritoneal production. Chapter 6 took this information and proposed that changes in the peritoneal cell population would change with time on PD and that this underpinned changes in ECM processing systems with time on PD. Finally, using data from parallel proteomic interrogation of PDE being performed in the same laboratory, chapter 5 attempted to validate some of these data by classical ELISA in the patient cohorts available. The above chapters are important to identify markers of peritoneal injury (biomarkers) that could be monitored to provide indication of the development of peritoneal injury including PS and EPS. Biomarkers that can be measured in the PDE samples can potentially be used to monitor changes occurring in the peritoneal ECM in response to time on treatment. Therefore, the overall aims of this thesis were to identify biomarkers or diagnostic tools for PS and EPS.

This thesis proposes the hypothesis that there are proteins present in the peritoneal dialysis effluent that will inform on the rate of simple peritoneal sclerosis and EPS. These proteins are likely to be those involved in tissue remodeling or fibrosis. MMPs, TIMPs, and proteins identified by proteomics are examples on these potential proteins. To address this, each You use this word too often, consider replacing it withdivisionepisodememberaffiliatebranchphase
chapter
 sought to parts of this wider hypothesis. You use this word too often, consider replacing it withdivisionepisodememberaffiliatebranchphase
Chapter
 3 proposed that You use this word too often, consider replacing it withdevelopmentadvanceadjustmentdiversityshifttransition
changes
 in the MMP system in the peritoneum would underlie PS &/or the switch to EPS and may

244

have value as biomarkers or diagnostics in PDE while You use this word too often, consider replacing it withdivisionepisodememberaffiliatebranchphase
chapter
 4 This phrase/word (depending on the context) can be potentially replaced with :evaluated
tested
 the hypothesis that MMP family members had a peritoneal production. You use this word too often, consider replacing it withdivisionepisodememberaffiliatebranchphase
Chapter
 6 took this information and proposed that You use this word too often, consider replacing it withdevelopmentadvanceadjustmentdiversityshifttransition
changes
 in the peritoneal cell population would You use this word too often, consider replacing it withdevelopmentadvanceadjustmentdiversityshifttransition
change
 with time on PD and that this underpinned You use this word too often, consider replacing it withdevelopmentadvanceadjustmentdiversityshifttransition
changes
 in ECM processing systems with time on PD. Finally
, using data from parallel proteomic interrogation of PDE being performed
 in the same laboratory, You use this word too often, consider replacing it withdivisionepisodememberaffiliatebranchphase
chapter
 5 attempted to validate This phrase/word is too simple and can be replaced with:a number of
some
 of these data by classical ELISA in the patient cohorts available. The above You use this word too often, consider replacing it withdivisionepisodememberaffiliatebranchphase
chapters
 are This phrase/word is too simple and can be replaced with:vitalcriticalessential
important
 to identify markers of peritoneal injury (biomarkers) that could be monitored
 to provide indication of the development of peritoneal injury including PS and EPS. Biomarkers that can be measured
 in the PDE samples can potentially
 be This phrase/word (depending on the context) can be potentially replaced with :exploited
used
 to monitor You use this word too often, consider replacing it withdevelopmentadvanceadjustmentdiversityshifttransition
changes
 occurring in the peritoneal ECM in response to time on treatment. Therefore
, the overall
 aims of this thesis were to identify biomarkers or diagnostic tools for PS and EPS. 