Another type of non-optical sensor is based on detecting small changes in the mass of the sensor when exposed to chemical analytes through the physical adsorption of analytes on the sensor or specific chemical reactions of the analytes with the sensor. Mass sensors are usually microelectromechanical systems (MEMS). A typical mass sensor is a piezoelectric resonator with a polymer coating or an adsorbent molecular receptor. [117, 118] Molecular analytes in the sensor film cause physical or chemical adsorption that increases the mass of the sensor and thus decreases the resonant frequency. A common example of a mass sensor is the Quartz Crystal Balance (QCM), also known as bulk acoustic wave sensors [119, 120]. The principle of QCM-based diagnosis has many inherent benefits for the bioassay of disease. QCM systems can detect any type of molecule directly, because mass is an inherent feature of all materials, making it a versatile platform for detecting different types of disease biomarkers. Surface acoustic wave (SAW) sensors are a class of sensors based on two or more interdigitated transducers located on the surface of a piezoelectric layer that measure the delay of surface waves from one transducer to the other by piezoelectric [122 -124].
Another type of non-optical sensor
is based
on detecting
small
changes
in the
mass
of the sensor when exposed to chemical analytes through the physical adsorption of analytes on the sensor or specific chemical reactions of the analytes with the sensor.
Mass
sensors are
usually
microelectromechanical
systems (
MEMS
). A typical
mass
sensor is a piezoelectric resonator with a polymer coating or an adsorbent molecular receptor. [117, 118] Molecular analytes in the sensor film cause physical or chemical adsorption that increases the
mass
of the sensor and
thus
decreases the resonant frequency. A common example of a
mass
sensor is the Quartz Crystal Balance (QCM),
also
known as bulk acoustic wave sensors [119, 120]. The principle of QCM-based diagnosis has
many
inherent benefits for the
bioassay
of disease. QCM systems can detect any type of molecule
directly
,
because
mass
is an inherent feature of all materials, making it a versatile platform for detecting
different
types of disease biomarkers. Surface acoustic wave (
SAW
) sensors are a
class
of sensors based on two or more
interdigitated
transducers located on the surface of a piezoelectric layer that measure the delay of surface waves from one transducer to the other by piezoelectric [122 -124].